Science at multiQure

At multiQure, we regularly publish and present our scientific achievements in scientific journals and monographs, as well as at conferences and symposia around the world.

We consider this a perfect test of our ideas and a great means for the scientific community and experts from various fields to evaluate our results. This is also a means of continuous development at the highest level and according to the best scientific standards worldwide.

RNAi · Publications
RNAi · Patents
Immunooncology · Publications
Immunooncology · Posters

RNAi

CAG-targeting artificial miRNA with reduced off-target risk for efficient lowering of pathogenic polyglutamine proteins
April 1
2026

CAG-targeting artificial miRNA with reduced off-target risk for efficient lowering of pathogenic polyglutamine proteins

NAR Molecular Medicine Vol. 3 April 2026
Link
A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
June 1
2022

A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease

Molecular Therapy: Nucleic Acids Vol. 28 June 2022
Link
Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression
March 1
2020

Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression

Molecular Therapy: Nucleic Acids Vol. 19 March 2020
Link

Patents

Nucleic acid molecule and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
October 31
2024

Nucleic acid molecule and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats

Olejniczak M., Kotowska-Zimmer A., Pewinska M., Lewicki P., Siemionow K.
United States Patent Application US 2024/0360443 A1
Link
Nucleic acid molecule and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
October 16
2024

Nucleic acid molecule and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats

Olejniczak M., Kotowska-Zimmer A., Pewinska M., Lewicki P., Siemionow K.
European Patent Application EP 4 446 415 A1
Link
Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
June 25
2019

Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats

Krzyzosiak W., Olejniczak M., Galka-Marciniak P., Fiszer A.
United States Patent US 10,329,566 B2
Link
Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
May 15
2018

Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats

Krzyzosiak W., Olejniczak M., Galka-Marciniak P., Fiszer A.
United States Patent US 9,970,004 B2
Link

Immunooncology

Integrin Alpha v Beta 6 and Its Implication in Cancer Treatment
October 15
2022

Integrin Alpha v Beta 6 and Its Implication in Cancer Treatment

Brzozowska E., Deshmukh S.
"International Journal of Molecular Sciences" (2022)
Link
pH-responsive antibodies for therapeutic applications
January 22
2021

pH-responsive antibodies for therapeutic applications

Klaus T., Deshmukh S.
"Journal of Biomedical Science" (2021)
Link
In Chemico Modification of Nucleotides for Better Recognition
October 1
2018

In Chemico Modification of Nucleotides for Better Recognition

Jurek P., Matusiewicz M., Mazurek M., Jelen F.
Y. Dong (red.) "Aptamers for Analytical Applications" (2018)
Link

Posters

Generation of chemically modified aptamers to capture human C5 complement component in myasthenia gravis treatment
April 5
2022

Generation of chemically modified aptamers to capture human C5 complement component in myasthenia gravis treatment

Guzdek J., Majewska J., Piskorz M., Velez Pires F., Dobosz P., Carter D., Krzaczek K., Bąkowski T., Sok-Grochowska A.
Aptamers 2022, Oxford, UK
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Development of a bispecific antibody for colorectal cancer: Functional activity evaluation via a biophysical cell-based assay and surface plasmon resonance
October 25
2021

Development of a bispecific antibody for colorectal cancer: Functional activity evaluation via a biophysical cell-based assay and surface plasmon resonance

Pires F., Skulski M., Dudek A., Dobosz P., Kołodziejski J., Carter D.
EMBO Practical Course - Biomolecular interaction analysis 2021: From molecules to cells
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Chemically-modified aptamers generation to recognize relevant bacterial antigens and antibiotic resistance proteins
April 15
2021

Chemically-modified aptamers generation to recognize relevant bacterial antigens and antibiotic resistance proteins

Czarnecka M., Puchała M., Guzdek J., Radzińska M., Carter D., Darżynkiewicz ZM., Sołtys K., Adamowicz-Skrzypowska A., Ahmadi Y., Barišić I., Sok-Grochowska A.
Aptamers Virtual 2021, Oxford, UK
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Aptamer-enabled adsorber device for specific removal of anti-aquaporin-4 antibodies
September 3
2020

Aptamer-enabled adsorber device for specific removal of anti-aquaporin-4 antibodies

Czarnecka M., Puchała M., Guzdek J., Radzińska M., Dąbrowska B., Sok-Grochowska A., Lopko M., Sołtys K., Darżynkiewicz Z., Liputa E., Carter D., Żurek A., Bąkowski T.
Aptamers Virtual 2020, Oxford, UK
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Development Of A Fully Human Antibody Against A Key Immune Checkpoint Modulator
November 18
2019

Development Of A Fully Human Antibody Against A Key Immune Checkpoint Modulator

Dudek A., Kasprzyk O., Klaus T., Opalinska M., Swiat M., Kolodziejski J., Blaszczyk R., Dzwigonska M., Sydor P., Kolodziejczyk R., Poznar M., Carter D., Soltys K., Wawrzyniak M., Deshmukh S.
PEGS, Lisbon, Portugal
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Discovery Of Antibodies For Immunotherapy Of CRC Using A Proprietary Phage Display Platform
November 18
2019

Discovery Of Antibodies For Immunotherapy Of CRC Using A Proprietary Phage Display Platform

Kasprzyk O., Klaus T., Witkowicz A., Wilgan B., Swiderski L., Zurek A., Dudek A., Berezowski M., Kostyn A., Blazejewska A., Orlowski M., Krzaczek K., Sztyler M., Jakimowicz P., Soltys K., Carter D., Wawrzyniak M., Deshmukh S.
PEGS, Lisbon, Portugal
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PureSelect2 - a novel phage display platform for in vitro selection of therapeutic antibody fragments
April 30
2018

PureSelect2 - a novel phage display platform for in vitro selection of therapeutic antibody fragments

Matusiewicz, M., Sok, A., Margas, E., Swiat, M., Zurek, A., Wilgan, B.
PEGS, Boston, USA
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Modular platform for modified aptamers – a selection case study
April 11
2018

Modular platform for modified aptamers – a selection case study

Jurek P., Adamowicz A., Sok A., Mazurek M.
Aptamers 2018, Oxford, UK
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Modular platform for modified aptamers
June 28
2017

Modular platform for modified aptamers

Jurek P., Adamowicz A., Sok A., Mazurek M.
Aptamers-in-Bordeaux 2017, Bordeaux, France
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Phage Display and SELEX brought together – a bivalent aptamer-antibody conjugate for VEGFR specific targeting
March 31
2015

Phage Display and SELEX brought together – a bivalent aptamer-antibody conjugate for VEGFR specific targeting

Jurek, P., Matusiewicz, M., Piksa, M., P. Mazurek, MP., Jakimowicz, P., Jeleń, F.
Aptamers 2015, Oxford, UK
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