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RNA interference (RNAi) is a natural cellular process which takes part in the regulation of gene expression and it is also a mechanism of defense against viruses and mobile genomic elements. The basis for RNA interference is the participation of short double-stranded RNA molecules (dsRNA), 20-30 nucleotide long, in selective silencing of gene expression.
These molecules together with specific proteins form RNA-Induced Silencing Complex (RISC) in cells. Active RISC recognizes and binds to complementary sequences within mRNA, and leads to degradation of the transcript or to translation inhibition, depending on the level of complementarity.
Application of multiQure™ proprietary vectors and promoters gives the possibility to regulate expression of interfering RNA of shRNA- and sh-miR-type, their selective delivery to the tissues of interest and most importantly a long-term silencing effect.